IMMOBILIZED BIOACTIVE SUBSTANCE HAVING HIGH BIOLOGICAL ACTIVITY

摘要

PROBLEM TO BE SOLVED: To provide a medical instrument having a substrate material covered or coated by an improved method.SOLUTION: A medical instrument includes: a substrate material; a polymer coating material bonded to at least a part of the surface of the substrate material, to at least a part of which a plurality of bioactive substances having heparin cofactor II binding activity with at least 5 (pmol/cm2) of heparin cofactor II are covalent-bonded; and a biocompatible composition bonded to the polymer coating material. The biocompatible composition has antithrombin III binding activity.