INHIBITORS OF NOTUM PECTINACETYLESTERASE AND METHODS OF THEIR USE

摘要

Compounds are disclosed for the treatment, management and prevention of diseases and disorders affecting the bone. Particular compounds are potent inhibitors of Notum Pectinacetylesterase, and are of the formula: wherein E, G, Y, Z, R1, R2, and R3 are defined herein.