发明名称 |
Localized delivery of nucleic acid by polyelectrolyte assemblies |
摘要 |
The present invention provides implantable medical devices coated with polyelectrolyte assemblies that are fabricated by layer-by-layer deposition of nucleic acid and polycation. Such devices facilitate the local delivery of a nucleic acid contained in the polyelectrolyte assembly into a cell or tissue at an implantation site. Also provided are methods of fabricating and using implantable medical devices according to the invention. |
申请公布号 |
US8734851(B2) |
申请公布日期 |
2014.05.27 |
申请号 |
US20060414818 |
申请日期 |
2006.05.01 |
申请人 |
LYNN DAVID M.;ZHANG JINGTAO;JEWELL CHRISTOPHER M.;FREDIN NATHANIEL J.;WISCONSIN ALUMNI RESEARCH FOUNDATION |
发明人 |
LYNN DAVID M.;ZHANG JINGTAO;JEWELL CHRISTOPHER M.;FREDIN NATHANIEL J. |
分类号 |
A61K9/16;A61K9/14;A61K47/44;C12N15/00;C12N15/87;C12N15/88;C12Q1/68 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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