发明名称 |
METHOD AND DEVICE FOR IDENTIFICATION OF ONE CARBON PATHWAY GENE VARIANTS AS STROKE RISK MARKERS, COMBINED DATA MINING, LOGISTIC REGRESSION, AND PATHWAY ANALYSIS |
摘要 |
The disclosure provides method and device using a whole genome association analysis toolset for a total stroke case, versus a control group, which demonstrated significant associations with p less than 1.00E.03 for 5 genes, including polymorphisms in MTHFR, MTRR, and BHMT. These gene polymorphisms in MTHFR may remove or create intron and exon splice enhancer sites that affect alternative splicing activity as well as appropriate mRNA and protein production. |
申请公布号 |
US2014142060(A1) |
申请公布日期 |
2014.05.22 |
申请号 |
US201314084039 |
申请日期 |
2013.11.19 |
申请人 |
STEIN STUART A.;STEIN REED M.;HYDE PARK WEST, LLC |
发明人 |
STEIN STUART A.;STEIN REED M. |
分类号 |
C12Q1/68;A61K31/7056 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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