发明名称 |
Aldehyde tags, uses thereof in site-specific protein modification |
摘要 |
The invention features compositions and methods for site-specific modification of proteins by incorporation of an aldehyde tag. Enzymatic modification at a sulfatase motif of the aldehyde tag through action of a formylglycine generating enzyme (FGE) generates a formylglycine (FGly) residue. The aldehyde moiety of FGly residue can be exploited as a chemical handle for site-specific attachment of a moiety of interest to a polypeptide. |
申请公布号 |
US8729232(B2) |
申请公布日期 |
2014.05.20 |
申请号 |
US20090921131 |
申请日期 |
2009.03.20 |
申请人 |
RUSH JASON S.;BERTOZZI CAROLYN;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
RUSH JASON S.;BERTOZZI CAROLYN |
分类号 |
C07K1/00;C07K16/00;C12N11/00 |
主分类号 |
C07K1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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