| 发明名称 |
Preparation of N-alkylated opiates by reductive amination |
| 摘要 |
The present invention is directed to the reduction of an N-imine moiety or a hemiaminal moiety of a morphinan in the presence of a ruthenium, rhodium, or iridium asymmetric catalyst and a hydrogen source. |
| 申请公布号 |
US8729266(B2) |
申请公布日期 |
2014.05.20 |
| 申请号 |
US20080668900 |
申请日期 |
2008.06.16 |
| 申请人 |
GROTE CHRISTOPHER W.;ORR BRIAN;JIANG TAO;CANTRELL GARY L.;MALLINCKRODT LLC |
发明人 |
GROTE CHRISTOPHER W.;ORR BRIAN;JIANG TAO;CANTRELL GARY L. |
| 分类号 |
C07D489/02 |
主分类号 |
C07D489/02 |
| 代理机构 |
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| 地址 |
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