| 摘要 |
<p>Substituted anionic compounds comprising a backbone formed of a discrete number of 1-8 of identical or different saccharide units linked by identical or different glycosidic bonds, are new. The saccharide units comprise pentoses, hexoses, uronic acids, and N-acetylhexosamine in cyclic form or reduced form. The substituted anionic compounds are randomly substituted by: a substituent (I), where the degree of substitution (j) is 0.01-6; and optionally, substituents, where the degree of substitution (i) is 0 to 6-j. Substituted anionic compounds comprising a backbone formed of a discrete number of 1-8 of identical or different saccharide units linked by identical or different glycosidic bonds, are new. The saccharide units comprise pentoses, hexoses, uronic acids, and N-acetylhexosamine in cyclic form or reduced form. The substituted anionic compounds are randomly substituted by: a substituent of formula -[R1] a-[[AA]-[R2] n] m (I), where the degree of substitution (j) is 0.01-6; and optional substituents R1a, where the degree of substitution (i) is 0 to 6-j. -[AA]- : amino acid residue optionally having n radicals, where -R2 is located in a backbone of the compound via a link arm, and -R1 is directly linked to the backbone by G1; -R1 : bond (when a is 0), optionally substituted 1-5C-carbon chain (when a is 1) comprising at least one heteroatoms (consisting of O, N or S) and having at least one acid functional group before the reaction with the amino acid, where the carbon chain is formed with the amino acid residue, or amide bond attached to saccharide backbone using a function F1 resulting from a reaction between a hydroxyl function carried by the backbone and a function carried by the -R1- precursor; -R2 : optionally substituted 1-30C-carbon chain optionally comprising at least one heteroatoms O, N or S and/or one or more cyclic groups, where R2 is formed with the amino acid residue of binding ester, carbamate, amide, and ether resulting from a reaction between a function carried by R2 and a function carried by -AA- precursor; F1 : ether, ester, amide or carbamate; G1 : ester, carbamate, or amide; n : 0, 1, or 2; m : 1 or 2; R1a : optionally substituted 1-15C-carbon chain comprising at least one heteroatoms (consisting of O, N or S) and having at least one acid functional group in the form of salt of alkaline cations attached to the backbone using a function F2 resulting from a reaction between hydroxyl or carboxylic acid functionally carried by the backbone and a functional group carried by -R1a precursor; and F2 : ether, ester, amide, or carbamate. An independent claim is included for a pharmaceutical composition comprising an anionic compound and an active ingredient consisting of proteins, glycoprotein, peptides and non-peptide therapeutic molecules.</p> |
