PEG MODIFIED EXENDIN OR EXENDIN ANALOG AND COMPOSITION AND USE THEREOF

摘要

PROBLEM TO BE SOLVED: To provide exendin or exendin analog which overcomes existing defects of known exendin and exendin analog including short time intervals between doses, the production of antibodies in patients from long-term injection, and the reduction of bioactivity after modification with PEG.SOLUTION: Exendin or exendin analog modified by one or more PEG derivative that may be linked to one or more amino acids of the exendin or exendin analog is provided. The PEG derivative may have a branched structure represented by formula I, for example. Compositions including the PEG derivative modified exendin or exendin analog, a method of making or administering the modified exendin or exendin analog, and various uses thereof are also provided.