发明名称 |
(E)-N-monoalkyl-3-oxo-3-(2-thienyl) propenamine and process for producing the same and process for producing (E,Z)-N-monoalkyl-3-oxo-3-(2-thienyl) propenamine |
摘要 |
The present invention provides a process for producing (E)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine represented by Formula (1); wherein R is a C1-4 alkyl, the method comprising the steps of: maintaining a solution containing (Z)—N-monoalkyl-3-oxo-3-(2-thienyl)propenamine dissolved therein at 25° C. or below to deposit crystals and separating crystals having a particle diameter of 100μm or less from the deposited crystals; and a process for producing (E,Z)—N-monoalkyl-3-oxo-3-(2-thienyl)propenamine comprising the steps of: reacting an alkali metal salt ofβ-oxo-β-(2-thienyl)propanal with a monoalkylamine compound; adding a water-insoluble organic solvent to the resulting reaction mixture; adding seed crystals containing (E)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine to an organic layer obtained by conducting separation; and keeping the resulting mixture at 25° C. or below. |
申请公布号 |
US8722906(B2) |
申请公布日期 |
2014.05.13 |
申请号 |
US201213396972 |
申请日期 |
2012.02.15 |
申请人 |
SATAKE SYUZO;HAYASHIZAKA NORIYUKI;FUSEYA ICHIRO;TANAKA MUNEAKI;KAGANO HIROKAZU;SUMITOMO SEIKA CHEMICALS CO., LTD. |
发明人 |
SATAKE SYUZO;HAYASHIZAKA NORIYUKI;FUSEYA ICHIRO;TANAKA MUNEAKI;KAGANO HIROKAZU |
分类号 |
C07D333/22 |
主分类号 |
C07D333/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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