The present disclosure describes antibodies that target CD19, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an Fcg³R or alters effector function as compared to the parent antibody. Also disclosed are methods of using said antibodies.
申请公布号
HRP20140331(T1)
申请公布日期
2014.05.09
申请号
HR2014P000331T
申请日期
2014.04.07
申请人
XENCOR, INC.
发明人
BERNETT, MATTHEW J.;CHU, SEUNG YUP;DESJARLAIS, JOHN R.;KARKI, SHER BAHADUR;LAZAR, GREGORY ALAN;PONG, ERIK WEIKING;RICHARDS, JOHN O.;ZHUKOVSKY, EUGENE ALEXANDER