发明名称 |
NOVEL LIPIDOMIMETIC COMPOUNDS AND USES THEREOF |
摘要 |
Disclosed are lipidomimetic compounds of formula I (I) wherein: G represents a group satisfying formula II: HO—CH2—{CH(OH)—CH2-0}m-CH2—{C(=0)-0-CH2})q—formula II each n independently is an integer from 1-30; m is an integer from 1-10; q is 0 or 1. These compounds can be added to the lipid bilayer of thermosensitive liposomes, for the purpose of aiding in the prevention of leakage of the liposomes' contents at 37° C., and retarding clearance from circulation. |
申请公布号 |
US2014127135(A1) |
申请公布日期 |
2014.05.08 |
申请号 |
US201214122253 |
申请日期 |
2012.06.06 |
申请人 |
GRUELL HOLGER;LANGEREIS SANDER;LUB JOHAN;KONINKLIJKE PHILIPS N.V. |
发明人 |
GRUELL HOLGER;LANGEREIS SANDER;LUB JOHAN |
分类号 |
A61K47/14;A61K9/127;A61K49/18 |
主分类号 |
A61K47/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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