Process for the production of 7-chloro-6-demethyltetracycline

摘要

7-chloro-6-demethyltetracycline is prepared by cultivating a microorganism of the genus Streptomyces capable of producing 7-chloro-6-demethyltetracycline in a medium containing a source of chloride ions and ethionine and methionine compounds. The source of chloride ions may be sodium chloride, the ethionine compound may be ethionine or ethionine sulphoxide and the methionine compound may be methionine or methionine sulphoxide.