发明名称 |
METHOD FOR PRODUCING FINE PARTICLES OF ARIPIPRAZOLE ANHYDRIDE CRYSTALS B |
摘要 |
<p>The present invention provides a novel method for producing fine particles of aripiprazole anhydride crystals B. The method for producing fine particles of aripiprazole anhydride crystals B comprises the steps of: (1) heating and dissolving crude aripiprazole in a lower alcohol, and subsequently cooling the resulting mixture to precipitate crystals to obtain crystals of aripiprazole lower alcohol solvate; (2) subjecting the crystals of aripiprazole lower alcohol solvate to wet-milling in the form of a slurry containing the lower alcohol; and (3) subjecting the dispersion of the wet-milled crystals to solid-liquid separation to obtain the crystals, and heating the crystals.</p> |
申请公布号 |
EP2726461(A1) |
申请公布日期 |
2014.05.07 |
申请号 |
EP20120748263 |
申请日期 |
2012.06.29 |
申请人 |
OTSUKA PHARMACEUTICAL CO., LTD. |
发明人 |
BANDO, TAKUJI;YANO, KATSUHIKO;FUKANA, MAKOTO;AOKI, SATOSHI |
分类号 |
C07D215/22;A61K31/4704;A61P25/18 |
主分类号 |
C07D215/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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