发明名称 |
PROCESS FOR PRODUCING -SUBSTITUTED ESTER |
摘要 |
There is provided a process for producing an ±-substituted ester by reaction of a fluorosulfuric acid ester of ±-hydroxyester with a Grignard reagent in the presence of a zinc catalyst. It is newly found that the reaction for production of ±-substituted esters, in which the raw reaction substrate is limited to expensive trifluoromethanesulfonic acid esters, can proceed favorably with the use of fluorosulfuric acid esters suitable for mass-production uses. By the use of the fluorosulfuric acid ester high in optical purity, it is possible to obtain the ±-substituted ester with high optical purity upon inversion of the asymmetric carbon configuration. The process of the present invention can solve all of the prior art problems and can be applied for industrial uses. |
申请公布号 |
EP2357164(A4) |
申请公布日期 |
2014.05.07 |
申请号 |
EP20090826005 |
申请日期 |
2009.10.22 |
申请人 |
CENTRAL GLASS COMPANY, LIMITED |
发明人 |
AKIHIRO, ISHII;MANABU YASUMOTO |
分类号 |
C07C67/343;C07B53/00;C07B55/00;C07B61/00;C07C69/612;C07C303/24 |
主分类号 |
C07C67/343 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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