发明名称 |
Inhibition of DNA polymerases to augment chemotherapeutic and antimicrobial agents |
摘要 |
Disclosed herein is the identification of human DNA polymeraseκ(polκ) as the polymerase that mediates repair of DNA containing interstrand cros slinks (ICLs). The mechanism of action of a number of chemotherapeutic and antimicrobial agents is the induction of ICLs. Thus, provided herein is a method of enhancing the efficacy of a chemotherapeutic or antimicrobial agent in a subject, including selecting a subject in need of treatment with an ICL -inducing agent and administering to the subject an ICL-inducing agent and a therapeutically effective amount of an inhibitor of polκ. Also provided is a composition for treating a hyperproliferative disease, an autoimmune disease or an infectious disease, comprising an ICL-inducing agent and an amount of an inhibitor of polκsufficient to enhance the efficacy of the ICL-inducing agent. Further provided is a method of identifying a DNA polymerase inhibitor. |
申请公布号 |
US8715927(B2) |
申请公布日期 |
2014.05.06 |
申请号 |
US200913131936 |
申请日期 |
2009.04.22 |
申请人 |
LLOYD R. STEPHEN;MINKO IRINA G.;MCCULLOUGH AMANDA K.;OREGON HEALTH & SCIENCE UNIVERSITY |
发明人 |
LLOYD R. STEPHEN;MINKO IRINA G.;MCCULLOUGH AMANDA K. |
分类号 |
C12Q1/68;C07H21/00;C07H21/04;C12N9/10;C12Q1/48 |
主分类号 |
C12Q1/68 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|