发明名称 |
RECOMBINANT FACTOR VIII HAVING ENHANCED STABILITY FOLLOWING MUTATION AT THE A1-C2 DOMAIN INTERFACE |
摘要 |
The invention relates to a recombinant factor VIII that includes one or more mutations at an interface of A1 and C2 domains of recombinant factor VIII. The one or more mutations include substitution of one or more amino acid residues with either a cysteine or an amino acid residue having a higher hydrophobicity. This results in enhanced stability of factor VIII. Methods for making the recombinant factor VIII, pharmaceutical compositions containing the recombinant factor VIII, and use of the recombinant factor VIII for treating hemophilia A are also disclosed. |
申请公布号 |
US2014120071(A1) |
申请公布日期 |
2014.05.01 |
申请号 |
US201314141983 |
申请日期 |
2013.12.27 |
申请人 |
FAY PHILIP J.;WAKABAYASHI HIRONAO;UNIVERSITY OF ROCHESTER |
发明人 |
FAY PHILIP J.;WAKABAYASHI HIRONAO |
分类号 |
C07K14/755 |
主分类号 |
C07K14/755 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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