发明名称 |
BISPECIFIC BINDING MOLECULES FOR ANTI-ANGIOGENESIS THERAPY |
摘要 |
Bispecific binding molecules, in particular immunoglobulin single variable domains such as VHHs and domain antibodies, comprising a VEGF-binding component and a DII4-binding component in one molecule. Pharmaceutical compositions containing same and their use in the treatment of diseases that are associated with VEGF- and DII4-mediated effects on angiogenesis. Nucleic acids encoding the bispecific binding molecules, host cells and methods for preparing same. |
申请公布号 |
US2014120095(A1) |
申请公布日期 |
2014.05.01 |
申请号 |
US201313848826 |
申请日期 |
2013.03.22 |
申请人 |
BORGES ERIC;GSCHWIND ANDREAS;BOUCNEAU JOACHIM;DE TAVERNIER EVELYN;KOLKMAN JOOST;MERCHIERS PASCAL;VAN HOORICK DIANE;BOEHRINGER INGELHEIM INTERNATIONAL GMBH |
发明人 |
BORGES ERIC;GSCHWIND ANDREAS;BOUCNEAU JOACHIM;DE TAVERNIER EVELYN;KOLKMAN JOOST;MERCHIERS PASCAL;VAN HOORICK DIANE |
分类号 |
C07K16/22;C07K16/18 |
主分类号 |
C07K16/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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