ANTIBODIES WITH ENGINEERED IGG FC DOMAINS

摘要

Antibody Fc polypeptides are provided that efficiently bind to both Fcγ and Fcα receptors. In certain aspects, a Fc polypeptide comprises a chimeric IgG CH2 domain having a αl loop from IgA and an IgA CH3 domain. Recombinant antibodies comprising Fc polypeptides of the embodiments and methods for making and using such antibodies are likewise provided.