CYTOTOXIC AGENTS COMPRISING NEW TOMAYMYCIN DERIVATIVES AND THEIR THERAPEUTIC USE

摘要

THE INVENTION RELATES TO NOVEL TOMAYMICINE DERIVATIVES COMPRISING A LINKER. IT ALSO RELATES TO THE CONJUGATE MOLECULES THAT COMPRISE ONE OR MORE OF SAID TOMAYMICINE DERIVATIVES COVALENTLY LINKED TO A CELL BINDING AGENT THROUGH A LINKING GROUP THAT IS PRESENT ON THE LINKER OF THE TOMAYMYCIN DERIVATIVE. IT ALSO RELATES TO THE PREPARATION OF THE TOMAYMICINE DERIVATIVES AND OF THE CONJUGATE MOLECULES.