发明名称 |
COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE |
摘要 |
The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula (I); or a pharmaceutically acceptable salt, wherein the variables are as defined herein. |
申请公布号 |
WO2014062604(A1) |
申请公布日期 |
2014.04.24 |
申请号 |
WO2013US64920 |
申请日期 |
2013.10.15 |
申请人 |
VERTEX PHARMACEUTICALS INCORPORATED |
发明人 |
CHARRIER, JEAN-DAMIEN;PINDER, JOANNE;STORCK, PIERRE-HENRI |
分类号 |
C07D413/14;A61K31/496;A61P35/00;C07D413/04 |
主分类号 |
C07D413/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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