TARGETING OF THERAPEUTIC DRUGS AND DIAGNOSTIC AGENTS EMPLOYING COLLAGEN BINDING DOMAINS

摘要

A targeting composition comprising: (1) a therapeutic agent; (2) an intermediate release linker bound to the therapeutic agent; and (3) a targeting moiety bound to the intermediate release linker, the targeting moiety for binding the targeting composition to native collagen fibers, provides an improved means of targeting therapeutic agents to cells, particularly malignant cells. The therapeutic agents can be, but are not limited to, anti-neoplastic agents or anti-inflammatory agents. The peptide motif can be a motif derived from the sequence present in von Willebrand's factor. The invention also encompasses pharmaceutical compositions and methods of treatment, as well as diagnostic compositions.