发明名称 |
METHOD OF OBTAINING 17ALPHA-ACETOXY-11BETA-(4-N,N-DIMETHYLAMINOPHENYL)-19-NORPREGNA-4,9-DIENE-3,20-DIONE |
摘要 |
The process comprises (a) forming 1/ alpha -acetoxy-11 beta -(4-N,N-dimethylaminophenyl)-19-norpregna-4,9-dione-3,20-dione (VA-2914) isopropanol hemisolvate crystals by dissolving in isopropanol and subsequently crystallising; (b) separating the VA-2914 isopropanol hemisolvate crystals; and (c) converting said VA-2914 isopropanol hemisolvate into VA-2914. The VA-2914 compound is a steroid with anti-progestational and anti-glucocorticoid activity, useful in therapeutic and contraceptive gynaecological indications and in treating Cushing's syndrome and glaucoma. |
申请公布号 |
EP1602662(B1) |
申请公布日期 |
2014.04.23 |
申请号 |
EP20040703805 |
申请日期 |
2004.01.21 |
申请人 |
CRYSTAL PHARMA S.A.U |
发明人 |
SILVA GUISASOLA, LUIS OCTAVIO;GUTIERREZ FUENTES, LUIS GERARDO;ROSON NINO, CARLOS |
分类号 |
C07J41/00;C07J7/00;C07J21/00 |
主分类号 |
C07J41/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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