Biological materials and uses thereof

摘要

The invention provides a compound comprising a photosensitizing agent coupled to a carrier molecule with a minimum coupling ratio of 3:1 wherein the carrier molecule has a binding specificity for a target cell. There is also provided a process of conjugation comprising the use of a first and second aprotic solvent and uses of the conjugated compounds. FR1         1         2         3 H1-H2 Locus 123456789012345678901234567890 VH1 1-3 1-02 QVQLVQSGAEVKKPGASVKVSCKASGYTFT 1-3 1-03 QVQLVQSGAEVKKPGASVKVSCKASGYTFT 1-3 1-08 QVQLVQSGAEVKKPGASVKVSCKASGYTFT 1-2 1-18 QVQLVQSGAEVKKPGASVKVSCKASGYTFT 1-U 1-24 QVQLVQSGAEVKKPGASVKVSCKVSGYTLT 1-3 1-45 QMQLVQSGAEVKKTGSSVKVSCKASGYTFT 1-3 1-46 QVQLVQSGAEVKKPGASVKVSCKASGYTFT 1-3 1-58 QMQLVQSGPEVKKPGTSVKVSCKASGFTFT 1-2 1-69 QVQLVQSGAEVKKPGSSVKVSCKASGGTFS 1-2 1-e QVQLVQSGAEVKKPGSSVKVSCKASGGTFS 1-2 1-f EVQLVQSGAEVKKPGATVKISCKVSGYTFT VH2 3-1/2-1 2-05 QITLKESGPTLVKPTQTLTLTCTFSGFSLS 3-1 2-26 QVTLKESGPVLVKPTETLTLTCTVSGFSLS 3-1 2-70 QVTLKESGPALVKPTQTLTLTCTFSCFSLS VH3 1-3 3-07 EVQLVESGGGLVQPGGSLRLSCAASGFTFS 1-3 3-09 EVQLVESGGGLVQPGRSLRLSCAASGFTFD 1-3 3-11 QVQLVESGGGLVKPGGSLRLSCAASGFTFS 1-1 3-13 EVQLVESGGSLVQPGGSLRLSCAASGFTFS 1-U 3-15 EVQLVESGGGLVKPGGSLRLSCAASGFTFS 1-3 3-20 EVQLVFSGGSVVRPGGSLRLSCAASGFTFD 1-3 3-21 EVQLVESGGGLVKPGGSLRLSCAASGFTFS 1-3 3-23 EVQLLESGGGLVQPGGSLRLSCAASGFTFS 1-3 3-30 QVQLVESSGGVVQPGRSLRLSCAASGFTFS 1-3 3-30.3 QVQLVESGGGVVQPGRSLRLSCAASGFTFS 1-3 3-30.5 QVQLVESGGGVVQPGRSLRLSCAASGFTFS FR2 CDR1    4 H1-H2 Locus 1ab2345 67890123456789 VH1 1-3 1-02 G--YYMH WVRQAPGQGLEWMG 1-3 1-03 S--YAMH WVRQAPGQRLEWMG 1-3 1-08 S--YDIN WVRQATGQGLEWMG 1-2 1-18 S--YGIS WVRQAPGQGLEWMG 1-U 1-24 E--LSMH WVRQAPGKGLEWMG 1-3 1-45 Y--RYLH WVRQAPGQALEWMG 1-3 1-46 S--YYMH WVRQAPGQGLEWMG 1-3 1-58 S--SAVQ WVRQARGQRLEWIG 1-2 1-69 S--YAIS WVRQAPGQGLEWMG 1-2 1-e S--YAIS WVRQAPGQGLEWMG 1-2 1-f D--YYMH WVQQAPGKGLEWMG VH2 3-1/2-1 2-05 TSGVGVG WIRQPPGKALEWLA 3-1 2-26 NARMGVS WIRQPPGKALEWLA 3-1 2-70 TSGMRVS WIRQPPGKALEWLA VH3 1-3 3-07 S--YWMS WVRQAPGKGLEWVA 1-3 3-09 D--YAMH WVRQAPGKGLEWVS 1-3 3-11 D--YYMS WIRQAPGKGLEWVS 1-1 3-13 S--YDMH WVRQATGKGLEWVS 1-U 3-15 N--AWMS WVRQAPGKGLEWVG 1-3 3-20 D--YGMS WVRQAPGKGLEWVS 1-3 3-21 S--YSMN WVRQAPGKGLEWVS 1-3 3-23 S--YAMS WVRQAPGKGLEWVS 1-3 3-30 S--YGMH WVRQAPGKGLEWVA 1-3 3-30.3 S--YAMH WVRQAPGKGLEWVA 1-3 3-30.5 S--YGMH WVRQAPGKGLEWVA