发明名称 |
Substituted N-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs as tyrosine receptor kinase BTK inhibitors |
摘要 |
In one aspect, the invention relates to substituted N-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of the BTK kinase; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the BTK kinase. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
申请公布号 |
US8703767(B2) |
申请公布日期 |
2014.04.22 |
申请号 |
US201213436963 |
申请日期 |
2012.04.01 |
申请人 |
BEARSS DAVID J.;VANKAYALAPATI HARIPRASAD;SORNA VENKATASWAMY;WARNER STEVEN L.;SHARMA SUNIL;UNIVERSITY OF UTAH RESEARCH FOUNDATION |
发明人 |
BEARSS DAVID J.;VANKAYALAPATI HARIPRASAD;SORNA VENKATASWAMY;WARNER STEVEN L.;SHARMA SUNIL |
分类号 |
A61K31/5377;A61K31/496;A61K31/505;C07D239/20;C07D403/02;C07D413/02 |
主分类号 |
A61K31/5377 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|