发明名称 |
Alkyl 3-((2-amidoethyl)amino)-8-azabicyclo[3.2.1]octane-8-carboxylate analogs as selective M1 agonists and methods of making and using same |
摘要 |
In one aspect, the invention relates to compounds having a general structure: which are useful as selective allosteric or bitopic agonists of the M1 muscarinic receptor; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurodegenerative diseases, including Alzheimer's Disease. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
申请公布号 |
US8697691(B2) |
申请公布日期 |
2014.04.15 |
申请号 |
US20100975331 |
申请日期 |
2010.12.21 |
申请人 |
CONN P. JEFFREY;LINDSLEY CRAIG W.;WOOD MICHAEL R.;GOGLIOTTI ROCCO D.;NISWENDER COLLEEN M.;MELANCON BRUCE J.;LEBOIS EVAN P.;VANDERBILT UNIVERSITY |
发明人 |
CONN P. JEFFREY;LINDSLEY CRAIG W.;WOOD MICHAEL R.;GOGLIOTTI ROCCO D.;NISWENDER COLLEEN M.;MELANCON BRUCE J.;LEBOIS EVAN P. |
分类号 |
C07D471/08;A61K31/439;A61K31/444;A61K31/4545;A61K31/5377 |
主分类号 |
C07D471/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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