| 摘要 |
FIELD: medicine.SUBSTANCE: declared products are presented in the form of suppositories and contain a mechanically active amorphous or amorphocrystalline calcium gluconate as an active substance and additives as a base. One of the declared agents contains hard fat, paraffin, cacao butter and Lutrol F68 as a base in specific proportions. The other agent contains Witepsol W35, Witepsol H15, kollidon CL and Cremophore RH-40 as a base in specific proportions.EFFECT: invention provides the agents with uniformly released active substances, prolonged action and applicability for unassisted use by the patients; the declared agents provide a wide spectrum of therapeutic activity, particularly the regulation of Ca2+ and phosphate exchange, reduced resorption and higher bone tissue density, Ca2+ replacement, improved Ca2+ intestinal absorption, phosphate renal re-absorption, bone mineralisation, improved blood coagulation, maintained stable cardiac function, and enabled neurotransmission.2 cl, 5 ex |
