摘要 |
FIELD: chemistry.SUBSTANCE: claimed invention relates to macrolide derivative, namely to hydrate of erythromycin salts, which has molecular formula CHNO·A·nHO, n=1, 5; 2; 3; 3.5; 5; 6 or 11, where A represents lactobionic acid or thiocyanic acid, with n=3; 3.5; 5; 6 or 11, if A is lactobionic acid and n=1.5; 2 or 3, if A represents thiocyanic acid. Hydrate possesses good water solubility and better stability in storage, which is convenient for production of medication for treatment and prevention in people and animals of infectious diseases caused by bacteria, mycoplasms or chlamydia, sensitive to erythromycin. Also claimed is method of obtaining hydrate of erythromycin salts and its application for preparation or purification of erythromycin.EFFECT: obtaining pharmaceutical composition, possessing antibacterial activity.14 cl, 20 ex, 12 tbl, 7 dwg |