METHOD OF PREPARING OLIGOMERIC COMPOUNDS USING MODIFIED CAPPING PROTOCOLS
摘要
<p>Provided herein are methods for the solid phase synthesis of oligomeric compounds wherein at least one of the capping steps has been modified. More particularly, methods are provided wherein one or more of the capping steps is omitted or performed using reduced equivalents of acetic anhydride. In certain embodiments, the methods provide an enhanced purity profile. In certain embodiments, the methods provide an increased yield. The methods provided herein also provide at least an economic advantage over currently used methods in that reduced amounts of the mixture of capping reagents are required.</p>
申请公布号
WO2014028739(A4)
申请公布日期
2014.04.10
申请号
WO2013US55146
申请日期
2013.08.15
申请人
ISIS PHARMACEUTICALS, INC.;GENZYME CORPORATION
发明人
CEDILLO, ISAIAH, E.;JANCZAK, DARREN;WEAVER, PHILLIP, MICHAEL