ENERGY ABSORBING-BASED DIAGNOSTIC AND THERAPEUTIC METHODS EMPLOYING NUCLEIC ACID MOLECULES ENCODING CHROMOPHORE-PRODUCING ENZYMES

摘要

Provided are diagnostic and therapeutic methods using a composition containing a nucleic acid encoding a chromophore-producing enzyme(s), such as a melanin-producing enzyme or enzymes. The nucleic acid molecules can be used for directed or localized delivery to tumors or other cells associated with disease resulting in production of a chromophore product that can be used for diagnosis and therapy, including of tumors and metastases.