发明名称 |
HEXAHYDRODIBENZO[A,G]QUINOLIZINE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND USE THEREOF |
摘要 |
<p>The present invention relates to a novel hexahydrodibenzo[a,g]quinoline compound represented by general formula (I) and its derivatives, enantiomer, diastereoisomer, raceme and mixtures thereof, as well as pharmaceutically acceptable salts thereof. The present invention further relates to a method for preparing the compound, and the compound has good prevention and treatment effect on neurological diseases, especially diseases associated with dopamine receptor and 5-hydroxytryptamine receptor. The bioactivity experiment demonstrates that, the compound is expected to be developed into a novel and potent chemical entity for treating diseases associated with dopamine receptor and 5-hydroxytryptamine receptor, especially schizophrenia, Parkinson's disease, drug addiction, migraine and so on.</p> |
申请公布号 |
EP2716640(A1) |
申请公布日期 |
2014.04.09 |
申请号 |
EP20120793899 |
申请日期 |
2012.04.09 |
申请人 |
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES |
发明人 |
LIU, HONG;ZHEN, XUECHU;SUN, HAIFENG;ZHU, LIYUAN;LI, ZENG;JIANG, HUALIANG;CHEN, KAIXIAN;XIE, XIN;LI, JING;CHEN, YING |
分类号 |
C07D455/03;A61K31/4375;A61P25/06;A61P25/16;A61P25/18;A61P25/30 |
主分类号 |
C07D455/03 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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