发明名称 |
Antimicrobial activity of chicken NK-2 peptide against apicomplexan protozoa |
摘要 |
NK-2 synthetic peptide derived from cationic core region of porcine NK-lysin has an antimicrobial and antitumor polypeptide that is considered to play a pivotal role in innate defense immunity. To evaluate the antimicrobial properties of synthetic chicken NK-lysin peptides, we investigated cytolytic activity against apicomplexan parasites like Eimeria sporozoites, Neospora tachyzoites and Cryptosporidum sporozoites. The chicken NK-2 (cNK-2) lytic peptide which corresponds to amino acid residues of porcine NK-2 peptide significantly disrupted Eimeria and Cryptosporidum sporozoites and Neospora tachyzoites. In contrast, no bactericidal activity was observed on E. coli BMH71-18. The cNK-2 lytic peptide is novel antimicrobial agent which can be used to intervene and treat economically costly infections in the animal industry. |
申请公布号 |
US8691943(B2) |
申请公布日期 |
2014.04.08 |
申请号 |
US201113071112 |
申请日期 |
2011.03.24 |
申请人 |
LILLEHOJ HYUN SOON;LEE SUNG HYEN;HONG YEONG HO;THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE |
发明人 |
LILLEHOJ HYUN SOON;LEE SUNG HYEN;HONG YEONG HO |
分类号 |
A61K38/00;A01N37/18;A61K38/04;A61K51/00;A61P33/02;C07K1/00;C07K5/00;C07K7/00;C07K16/00;C07K17/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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