发明名称 |
HIGHLY SENSITIVE SURVEILLANCE USING DETECTION OF CELL FREE DNA |
摘要 |
Provided herein are methods and computer-readable storage media related to cell-free DNA and uses thereof to determine risk of a condition in a subject. In one embodiment, the method comprises analyzing nucleic acids from cell-free DNA extracted from a biological sample obtained from the subject to identify a plurality of loci, the nucleic acids comprising first nucleic acids of the subject and second nucleic acids not native to the subject; determining an allele of each of the plurality of loci; selecting at least one informative locus from the plurality of loci based on the determining of the allele; calculating an estimated allele frequency of a first allele at the at least one informative locus using a statistical distribution; determining an amount of cell-free DNA not native to the subject in the cell-free DNA based on the estimated allele frequency; and determining a risk in the subject. |
申请公布号 |
WO2013159035(A3) |
申请公布日期 |
2014.04.03 |
申请号 |
WO2013US37439 |
申请日期 |
2013.04.19 |
申请人 |
MEDICAL COLLEGE OF WISCONSIN, INC. |
发明人 |
MITCHELL, AOY, TOMITA;MITCHELL, MICHAEL |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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