C-TERMINAL AND CENTRAL EPITOPE A-BETA ANTIBODIES

摘要

The present invention provides antibodies directed against C-terminal and central epitopes ofΑβthat preferentially bind compact plaques relative to diffuse plaques. The invention also provides methods of treating patients to reduce or eliminate the presence of compact plaques ofΑβand associated symptoms. In one aspect, the present invention provides a method of treating a patient diagnosed with mid- or late-stage Alzheimer's disease, comprising administering to the patient an effective regime of an antibody that binds to an epitope within residues 12-43 ofΑβand preferentially binds compact plaques relative to diffuse plaques. In some cases, the patient has been diagnosed with mid-stage Alzheimer's disease. In some cases, the patient has been diagnosed with late-stage Alzheimer's disease.