NEW CRYSTALLINE FORM OF ROSUVASTATIN METHYL ESTER AND PREPARATION METHOD THEREOF

摘要

Provided is a new crystalline form of methyl (E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino] pyrimidin-5-yl](3R,5S)-3,5-dihydroxy-6-heptenoate and preparation method thereof. The preparation method can obtain the crystalline form of methyl (E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino] pyrimidin-5-yl](3R,5S)-3,5-dihydroxy-6-heptenoate having less than 0.50% enantiotopic impurities and less than 0.30% diastereoisomeric impurities by solvent crystallization or pulping.