| 摘要 |
<p>A method is described for determining the efficacy of a treatment method for a patient having a tissue disorder by administering a treatment to the patient, measuring a hazard score at two or more points in time after administering the treatment by obtaining an image of a tissue of the patient, wherein the image comprises a plurality of patient image voxels, identifying voxels of the patient image that are damaged by the disorder as damaged patient image voxels, obtaining a hazard atlas of the disorder in the tissue, wherein the hazard atlas comprises a plurality of voxels, each voxel representing a hazard value of an extent of deficit caused by damage from the disorder to that voxel of tissue at that location, and computing a hazard score for the patient, wherein the score is the integration of all damaged patient image voxels weighted by a hazard value corresponding to that voxel location, wherein the hazard score determines the patient's prognosis, and determining the efficacy of the treatment based on the hazard scores. Further, a hazard atlas and methods for generating a hazard atlas are described.</p> |
