| 摘要 |
The present invention relates to new spiroepoxide tetrahydrobenzo-triazole and - imidazole compounds, a method for their production and their use as MetAP-II inhibitors, which are particularly useful as inhibitors of angiogenesis. The compounds are characterized by formula (I)
X=CorN
R 1 = OC(O)R 2 where R 2 is alkyl, cycloalkyl, aryl, heteroaryl, or cinnamyl or
R 1 = OC(O)NHR 3 where R 3 is alkyl, cycloalkyl, aryl, or heteroaryl
or
R 1 = NHC(O)OR 4 where R 4 is alkyl
or
R 1 = OH, NH 2
R 5 = alkyl, cycloalkyl, CH 2 R 6 where R 6 is aryl or heteroaryl |
