摘要 |
The present invention relates to compounds of the Formula (I) and (II) wherein R, R21, R25-R33, m, n, X21-X23, and Q1 are defined herein. The compounds modulate protein kinase enzymatic activity to modulate cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly p70S6 and/or Akt kinases. Methods of using and preparing the compounds, and pharmaceutical compositions thereof, to treat kinase-dependent diseases and conditions are also an aspect of the invention. |
申请人 |
EXELIXIS, INC. |
发明人 |
ANAND, NEEL K.;BLAZEY, CHARLES M.;BOWLES, OWEN JOSEPH;BUSSENIUS, JOERG;CANNE BANNEN, LYNNE;CHAN, DIVA SZE-MING;CHEN, BAILI;CO, ERICK WANG;COSTANZO, SIMONA;DEFINA, STEVEN CHARLES;DUBENKO, LARISA;FRANZINI, MAURIZIO;HUANG, PING;JAMMALAMADAKA, VASU;KHOURY, RICHARD GEORGE;KIM, MOON HWAN;KLEIN, RHETT RONALD;LE, DONNA TRA;MAC, MORRISON B.;NUSS, JOHN M.;PARKS, JASON JEVIOUS;RICE, KENNETH D.;TSANG, TSZE H.;TSUHAKO, AMY LEW;WANG, YONG;XU, WEI |