Methods and agents for improving targeting of CD138 expressing tumor cells
摘要
Disclosed are immunoconjugates having specificity for CD138 that diminish adhesion of CD138 expressing tumor cells to stroma cells and methods of using the same. This deminished adhesion renders the tumor cells not only susceptible to the immunconjugate, but also to other agents, in particular cytotoxic agents.
申请公布号
AU2008339913(B2)
申请公布日期
2014.03.20
申请号
AU20080339913
申请日期
2008.12.23
申请人
BIOTEST AG;DANA-FARBER CANCER INSTITUTE, INC.;IMMUNOGEN, INC
发明人
ANDERSON, KENNETH;DAELKEN, BENJAMIN;BRUECHER, CHRISTOPH;HIDESHIMA, TERU;UHEREK, CHRISTOPH