发明名称 |
Preparation of tetrahydropyrido[4,3-b]indole derivatives |
摘要 |
<p>The present invention relates to a sustained-release composition containing 2,3,4,5-tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole or a pharmaceutically acceptable salt thereof as an active ingredient, preparation thereof and the compound. The composition is suitable for oral administration by one time per day, and achieves the peak plasma concentration at 1.0 to 3 hours after oral administration. The composition is suitable for manufacturing a medicament for treatment of cognitive dysfunction syndrome, Alzheimer's disease, Parkinson's disease, Huntington's disease, or senile dementia.</p> |
申请公布号 |
EP2581374(B1) |
申请公布日期 |
2014.03.19 |
申请号 |
EP20120197026 |
申请日期 |
2010.03.29 |
申请人 |
INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA |
发明人 |
LI, SONG;ZHONG, WU;ZHENG, ZHIBING;XIAO, JUNHAI;LI, BING;XIE, YUNDE;ZHOU, XINBO |
分类号 |
A61K31/44;A61K9/16;A61K9/20;C07D471/04 |
主分类号 |
A61K31/44 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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