发明名称 |
PROCESS FOR PRODUCING 1-(3,4-DICHLOROBENZYL)-5-OCTYLBIGUANIDE OR A SALT THEREOF |
摘要 |
The present invention provides a process for producing 1-(3,4-dichlorobenzyl)-5-octylbiguanide or a salt thereof, the process comprising reacting 1-cyano-3-octylguanidine or a salt thereof, with 3,4-dichlorobenzylamine or a salt thereof, in an ester-based organic solvent. According to the present invention, the reaction can be carried out at a low temperature using general-purpose equipment, and 1-(3,4-dichlorobenzyl)-5-octylbiguanide or a salt thereof can be produced in a high yield by a safe and easy process. |
申请公布号 |
CA2661272(C) |
申请公布日期 |
2014.03.18 |
申请号 |
CA20072661272 |
申请日期 |
2007.08.28 |
申请人 |
OTSUKA PHARMACEUTICAL CO., LTD. |
发明人 |
OKAICHI, YOSHIHIKO;TADA, NOBUHITO;NOMI, DAISUKE;FUJITA, NOBUHISA;TSUJI, KOICHI;YAMAGUCHI, TAIZO;MUGURUMA, YASUAKI;TSUJIMORI, HISAYUKI |
分类号 |
C07C277/08;C07C279/26 |
主分类号 |
C07C277/08 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|