发明名称 |
2-cianopirrolidinas n-substituídas, composição farmacêutica que as compreende e uso das mesmas |
摘要 |
The present invention relates to a compound of formula (I) wherein R is substituted adamantyl; and n is 0 to 3; in free form or in acid addition salt form. Compounds of formula I inhibit DPP-IV (dipeptidyl-peptidase-IV) activity. They are therefore indicated for use as pharmaceuticals in inhibiting DPP-IV and in the treatment of conditions mediated by DPP-IV, such as non-insulin-dependent diabetes mellitus, arthritis, obesity, osteoporosis and further conditions of impaired glucose tolerance. |
申请公布号 |
BR9915985(B1) |
申请公布日期 |
2014.03.18 |
申请号 |
BR19999915985 |
申请日期 |
1999.12.09 |
申请人 |
NOVARTIS AG (NOVARTIS SA) (NOVARTIS INC.) |
发明人 |
EDWIN BERNARD VILLHAUER |
分类号 |
C07D207/16;A61K31/40;A61K31/401;A61K31/4015;A61P3/04;A61P3/10;A61P43/00 |
主分类号 |
C07D207/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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