| 摘要 |
<p>The invention proposes a sensor device (10) and a method of sampling. The method comprises the steps of: A. adding a sample to a chamber (12) in which magnetic particles (P) are provided, the sample including a target component (T) and the chamber (12) having a detection surface (122); B. exerting a magnetic force on the magnetic particles (P) to attract the magnetic particles (P) to the detection surface (122), wherein bound magnetic particles that capture the target component (T) in the magnetic particles (P) are held at the detection surface (122), and unbound magnetic particles that capture no target component (T) in the magnetic particles (P) are held at the detection surface (122) as well; C. altering the magnetic force exerted on the magnetic particles (P) to release the unbound magnetic particles from the detection surface (122); D. measuring the amount of the bound magnetic particles that are held at the detection surface (122); E. determining whether the amount of the bound magnetic particles that are held at the detection surface (122) is above a predetermined threshold; if no, performing the following steps of: exerting the magnetic force on the magnetic particles to attract the magnetic particles (P) to the detection surface (122); draining at least part of the sample out of the chamber (12) and adding a new sample to the chamber (12); altering the magnetic force exerted on the magnetic particles to release the unbound magnetic particles from the detection surface (122); and going back to perform the steps B to E. By doing so, the target component (T) is preconcentrated by repeating the steps of magnetically binding the target component (T) from the newly added sample and washing the detection surface (122) from unbound magnetic particles.</p> |
