发明名称 |
PHOTOCHEMICAL ACTIVATION OF SURFACES FOR ATTACHING BIOMATERIAL |
摘要 |
A water-soluble photo-activatable polymer including : a photo-activatable group adapted to be activated by an irradiation source and to form a covalent bond between the water-soluble photo-activatable polymer and a matrix having at least one carbon; a reactive group adapted to covalently react with a biomaterial for subsequent delivery of the biomaterial to a cell; a hydrophilic group; and a polymer precursor. A composition including a monomolecular layer of the water-soluble photo-activatable polymer and a matrix having at least one carbon, wherein the monomolecular layer is covalently attached to the matrix by a covalent bond between the photo-activatable group and the at least one carbon. The composition further includes a biomaterial having a plurality of active, groups, wherein the biomaterial is covalently attached to the monomolecular layer by covalent bonding between the active groups and reactive groups. Also provided is a method for delivery of a biomaterial to a cell. |
申请公布号 |
WO2014039799(A2) |
申请公布日期 |
2014.03.13 |
申请号 |
WO2013US58478 |
申请日期 |
2013.09.06 |
申请人 |
THE CHILDREN'S HOSPITAL OF PHILADELPHIA |
发明人 |
ALFERIEV, IVAN;FISHBEIN, ILIA;CHORNY, MICHAEL;LEVY, ROBERT, J.;YELLEN, BENJAMIN;WILLIAMS, DARRYL |
分类号 |
A61L27/16;A61L27/54;C08F120/06;C08F126/02 |
主分类号 |
A61L27/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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