发明名称 |
CSF-1R INHIBITORS FOR TREATMENT OF BRAIN TUMORS |
摘要 |
The present invention provides a compound of formula I; wherein R1 is an alkyl pyrazole or an alkyl carboxamide, and R2 is a hydroxycycloalkyl; or a pharmaceutically acceptable salt thereof, and compositions containing these compounds, for use to treat a brain tumor, particularly glioblastoma. The invention provides effective treatment of a brain tumor and can be used by oral administration of a compound of Formula I as further described herein. The invention also provides a method to treat a subject having a brain tumor such as glioblastoma, wherein the method comprises administering to the subject an effective amount of a compound of Formula I. Gene signatures correlated with successful treatment using these methods are also disclosed. |
申请公布号 |
EP2704713(A1) |
申请公布日期 |
2014.03.12 |
申请号 |
EP20120720761 |
申请日期 |
2012.05.04 |
申请人 |
NOVARTIS AG;SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH |
发明人 |
DANIEL, DYLAN;JOYCE, JOHANNA;SUTTON, JAMES |
分类号 |
A61K31/4439;A61K45/06;A61P35/00;C07D417/14 |
主分类号 |
A61K31/4439 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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