发明名称 |
AN ANTIBODY SPECIFICALLY BINDING TO INSULIN-LIKE GROWTH FACTOR-1 |
摘要 |
Herein is reported a fusion polypeptide according to formula (I): NH2—S2—X1—S1—COOH, wherein X1 comprises either a random amino acid sequence or an amino acid sequence derived from a first polypeptide, S2 and S1 are non-overlapping amino acid sequences derived from a second polypeptide, and denotes a peptide bond, wherein the second polypeptide is a polypeptide with peptidyl-prolyl cis/trans-isomerase activity (PPIase activity) or is derived from the FKBP-fold domain family, wherein X1 is inserted in place of the insert-in-flap-domain of the second polypeptide. |
申请公布号 |
EP2705053(A1) |
申请公布日期 |
2014.03.12 |
申请号 |
EP20120717787 |
申请日期 |
2012.05.04 |
申请人 |
ROCHE DIAGNOSTICS GMBH;F.HOFFMANN-LA ROCHE AG |
发明人 |
ANDRES, HERBERT;DUEFEL, HARTMUT;GERG, MICHAEL;KOWALEWSKY, FRANK;SCHOLZ, CHRISTIAN;SCHRAEML, MICHAEL |
分类号 |
C07K14/475;C07K14/65;C07K16/12;C07K16/22;C07K16/40;C12N9/90;G01N33/573;G01N33/74 |
主分类号 |
C07K14/475 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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