发明名称 |
COMPOSITIONS AND METHODS FOR INHIBITING ACTIVITY OF HYPOXIA-INDUCIBLE TRANSCRIPTION FACTOR COMPLEX AND ITS USE FOR TREATMENT OF TUMORS |
摘要 |
Disclosed are epidithiodiketopiperazine compounds, pharmaceutical compositions based thereon and methods of treating, reducing or inhibiting transcription and translation of hypoxia-inducible genes. An embodiment of the present invention is directed to a method for interfering with hypoxia-induced transcriptional pathway. Generally, the method according to this embodiment comprises contacting a cell with at least one compound according to either Formula I, Formula II or Formula III, or a salt, solvent or hydrate thereof. |
申请公布号 |
WO2014035484(A1) |
申请公布日期 |
2014.03.06 |
申请号 |
WO2013US32523 |
申请日期 |
2013.03.15 |
申请人 |
UNIVERSITY OF SOUTHERN CALIFORNIA |
发明人 |
OLENYUK, BOGDAN, Z.;DUBEY, RAMIN;LEVIN, MICHAEL, D. |
分类号 |
A61K31/4995 |
主分类号 |
A61K31/4995 |
代理机构 |
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代理人 |
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