发明名称 |
Unacylated ghrelin and analogs as therapeutic agents for vascular remodeling in diabetic patients and treatment of cardiovascular disease |
摘要 |
The present invention relates to a method for treating a cardiovascular disease, for increasing the number of circulating angiogenic cells (CAC) and/or improving the function of CAC and a method for improving vascular remodeling and/or neovascularisation. The method comprises administering to the subject a therapeutically effective amount of unacylated ghrelin or a polypeptide comprising the amino acid sequence set forth in SEQ ID NO: 1 or a fragment or analog thereof having the biological activity of SEQ ID NO: 1; and to pharmaceutical compositions comprising unacylated ghrelin or a polypeptide comprising the amino acid sequence set forth in SEQ ID NO: 1 or a fragment or analog thereof having the biological activity of SEQ ID NO: 1. |
申请公布号 |
AU2009256558(B2) |
申请公布日期 |
2014.03.06 |
申请号 |
AU20090256558 |
申请日期 |
2009.06.12 |
申请人 |
ALIZE PHARMA SAS |
发明人 |
MUCCIOLI, GIAMPIERO;BRIZZI, MARIA FELICE;GHIGO, EZIO |
分类号 |
A61K38/25;A61P9/00;A61P17/00 |
主分类号 |
A61K38/25 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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