发明名称 |
Novel KIF5B-RET fusion molecules and uses thereof |
摘要 |
Novel RET fusion molecules and uses are disclosed. In one embodiment, a KIF5B-RET fusion includes an in-frame fusion of an exon of KIF5B (e.g., one more exons encoding a kinesin motor domain or a fragment thereof) and an exon of RET (e.g., one or more exons encoding a RET tyrosine kinase domain or a fragment thereof). For example, the KIF5B-RET fusion can include an in-frame fusion of at least exon 15 of KIF5B or a fragment thereof (e.g., exons 1-15 of KIF5B or a fragment thereof) with at least ex on 12 of RET or a fragment thereof (e.g., exons 12-20 5 of RET or a fragment thereof). |
申请公布号 |
AU2012298884(A1) |
申请公布日期 |
2014.03.06 |
申请号 |
AU20120298884 |
申请日期 |
2012.08.23 |
申请人 |
FOUNDATION MEDICINE, INC. |
发明人 |
LIPSON, DORON;STEPHENS, PHILIP JAMES;PARKER, ALEXANDER N.;DOWNING, SEAN R.;HAWRYLUK, MATTHEW J. |
分类号 |
C07K14/82 |
主分类号 |
C07K14/82 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|