APPARATUS AND METHOD FOR SOLID PHASE SYNTHESIS

摘要

An apparatus for microwave assisted solid phase synthesis using solid-phase resin beads mixed with a liquid solvent comprises: - a generally cylindrical reactor (1) made of microwave transparent material and having a central axis, the reactor (1) having an inlet (5) and an outlet (6); - a porous frit associated with the outlet (6) of the reactor (1), the porous frit preventing discharge of beads and allowing discharge of the solvent from the reactor; and - means (4) for concentric rotation of the reactor (1) around the central axis in alternating clockwise and anti-clockwise directions. A method for microwave assisted solid phase synthesis using the apparatus is also disclosed.