发明名称 |
Chemical linkers with single amino acids and conjugates thereof |
摘要 |
The present disclosure provides drug-ligand conjugates that are potent cytotoxins and include a linker between the drug and ligand where the linker has a single amino acid. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them. |
申请公布号 |
US8664407(B2) |
申请公布日期 |
2014.03.04 |
申请号 |
US20080528316 |
申请日期 |
2008.02.20 |
申请人 |
CHEN LIANG;GANGWAR SANJEEV;GUERLAVAIS VINCENT;LONBERG NILS;ZHANG QIAN;MEDAREX, LLC |
发明人 |
CHEN LIANG;GANGWAR SANJEEV;GUERLAVAIS VINCENT;LONBERG NILS;ZHANG QIAN |
分类号 |
C07D403/00;A61K31/40;A61K31/497;C07D209/56;C12N5/071 |
主分类号 |
C07D403/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|